Article
Age and the association between apolipoprotein E genotype and Alzheimer disease: A cerebrospinal fluid biomarker-based case-control study.
PLoS medicine - 1 Aug 2020
Saddiki Hana, Fayosse Aurore, Cognat Emmanuel, Sabia Séverine, Engelborghs Sebastiaan, Wallon David, Alexopoulos Panagiotis, Blennow Kaj, Zetterberg Henrik, Parnetti Lucilla, Zerr Inga, Hermann Peter, Gabelle Audrey, Boada Mercè, Orellana Adelina, de Rojas Itziar, Lilamand Matthieu, Bjerke Maria, Van Broeckhoven Christine, Farotti Lucia, Salvadori Nicola, Diehl-Schmid Janine, Grimmer Timo, Hourregue Claire, Dugravot Aline, Nicolas Gaël, Laplanche Jean-Louis, Lehmann Sylvain, Bouaziz-Amar Elodie, Hugon Jacques, Tzourio Christophe, Singh-Manoux Archana, Paquet Claire, Dumurgier Julien
Abstract excerpt
BACKGROUND: The ε4 allele of apolipoprotein E (APOE) gene and increasing age are two of the most important known risk factors for developing Alzheimer disease (AD). The diagnosis of AD based on clinical symptoms alone is known to have poor specificity; recently developed diagnostic criteria based on biomarkers that reflect underlying AD neuropathology allow better assessment of the strength of the associations of...
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