Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Blood-Brain Barrier Dysfunction and Aβ42/40 Ratio Dose-Dependent Modulation with the ApoE Genotype within the ATN Framework.

International journal of molecular sciences - 29 Jul 2023

Toniolo Sofia, Di Lorenzo Francesco, Bernardini Sergio, Mercuri Nicola Biagio, Sancesario Giulia Maria

Abstract excerpt

The definition of Alzheimer's disease (AD) now considers the presence of the markers of amyloid (A), tau deposition (T), and neurodegeneration (N) essential for diagnosis. AD patients have been reported to have increased blood-brain barrier (BBB) dysfunction, but that has not been tested within the ATN framework so far. As the field is moving towards the use of blood-based biomarkers, the relationship between BBB...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease
Share to Amyloid beta-Peptides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Apolipoproteins E

Share to Biomarkers

Share to Blood-Brain Barrier

Share to Cognitive Dysfunction

Share to Peptide Fragments

Share to tau Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 37569528
DOI: 10.3390/ijms241512151
PMCID: PMC10418506

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Blood-Brain Barrier Dysfunction and Aβ42/40 Ratio Dose-Dependent Modulation with the ApoE Genotype within the ATN Framework.PMID 37569528Read ↗

Research progress on the role and mechanism of blood-brain barrier dysfunction in Alzheimer's diseaseSemantic proximity Read ↗

Alzheimer's disease: A matter of blood-brain barrier dysfunction?Semantic proximity Read ↗

Opposing patterns of blood-brain barrier permeability and Alzheimer's disease biomarkers across APOE genotype.Semantic proximity Read ↗

Detrimental Effects of ApoE ε4 on Blood–Brain Barrier Integrity and Their Potential Implications on the Pathogenesis of Alzheimer’s DiseaseSemantic proximity Read ↗

Increased blood-brain barrier permeability is associated with dementia and diabetes but not amyloid pathology or APOE genotype.Semantic proximity Read ↗

Association of APOE genotype with blood-brain barrier permeability in neurodegenerative disorders.Semantic proximity Read ↗

The Amyloid-β Pathway in Alzheimer’s DiseaseSemantic proximity Read ↗

Current application of neurochemical biomarkers in the prediction and differential diagnosis of Alzheimer's disease and other neurodegenerative dementias.Semantic proximity Read ↗

Differential Associations of APOEɛ2 and APOEɛ4 Genotypes with Cerebrospinal Fluid Biomarkers of Alzheimer's Disease in Individuals Without Dementia.Semantic proximity Read ↗

Spotlight on the Pathophysiological Trajectories Linked to Alzheimer’s Disease (AD): Blood-Brain Barrier (BBB); Neuroinflammation; APOE4 Allele and AD- Insulin Resistance (IR) Pathogenic LinkSemantic proximity Read ↗

Navigation Between Alzheimer’s Disease (AD) and Its Various Pathophysiological Trajectories: The Pathogenic Link to Neuroimmunology—Genetics and NeuroinflammationSemantic proximity Read ↗

Blood-brain barrier impairment in Alzheimer disease: stability and functional significance.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.