Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Differential associations of APOE-ε2 and APOE-ε4 alleles with PET-measured amyloid-β and tau deposition in older individuals without dementia.

European journal of nuclear medicine and molecular imaging - 1 Jul 2021

Salvadó Gemma, Grothe Michel J, Groot Colin, Moscoso Alexis, Schöll Michael, Gispert Juan Domingo, Ossenkoppele Rik

Abstract excerpt

PURPOSE: To examine associations between the APOE-ε2 and APOE-ε4 alleles and core Alzheimer's disease (AD) pathological hallmarks as measured by amyloid-β (Aβ) and tau PET in older individuals without dementia. METHODS: We analyzed data from 462 ADNI participants without dementia who underwent Aβ ([18F]florbetapir or [18F]florbetaben) and tau ([18F]flortaucipir) PET, structural MRI, and cognitive testing....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Alzheimer Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Amyloid beta-Peptides

Share to Apolipoprotein E2

Share to Apolipoprotein E4

Share to Cross-Sectional Studies

Share to Positron-Emission Tomography

Share to tau Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 33521872
DOI: 10.1007/s00259-021-05192-8
PMCID: PMC8175302

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Differential associations of APOE-ε2 and APOE-ε4 alleles with PET-measured amyloid-β and tau deposition in older individuals without dementia.PMID 33521872Read ↗

Differences in AD-related pathology profiles across APOE groupsSemantic proximity Read ↗

APOE ε2ε4 genotype, incident AD and MCI, cognitive decline, and AD pathology in older adults.Semantic proximity Read ↗

Effect of APOE ε4 genotype on amyloid-β and tau accumulation in Alzheimer’s diseaseSemantic proximity Read ↗

APOEε2 is associated with milder clinical and pathological Alzheimer disease.Semantic proximity Read ↗

Multiple Effect of APOE Genotype on Clinical and Neuroimaging Biomarkers Across Alzheimer's Disease Spectrum.Semantic proximity Read ↗

Differential Associations of APOEɛ2 and APOEɛ4 Genotypes with Cerebrospinal Fluid Biomarkers of Alzheimer's Disease in Individuals Without Dementia.Semantic proximity Read ↗

Effect of APOE ε4 genotype on amyloid-β and tau accumulation in Alzheimer's disease.Semantic proximity Read ↗

Opposing patterns of blood-brain barrier permeability and Alzheimer's disease biomarkers across APOE genotype.Semantic proximity Read ↗

Correlations between APOE4 allele and regional amyloid and tau burdens in cognitively normal older individualsSemantic proximity Read ↗

Association Between Apolipoprotein E ε2 vs ε4, Age, and β-Amyloid in Adults Without Cognitive Impairment.Semantic proximity Read ↗

APOE and amyloid-tau pathology in cognitively unimpaired older adultsSemantic proximity Read ↗

<i>APOE4</i>impact on soluble and insoluble tau pathology is mostly influenced by amyloid-betaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.