Cerebrospinal fluid proteomic associations of APOE genotypes reveal distinct protective and risk mechanisms for Alzheimer's disease.

doi:10.1002/alz.70738

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Article

Cerebrospinal fluid proteomic associations of APOE genotypes reveal distinct protective and risk mechanisms for Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Oct 2025

Vromen Eleonora M, Lageman Senne B, Gobom Johan, van der Kant Rik, Dobricic Valerija, Bertram Lars, Streffer Johannes, Lovestone Simon, Vos Stephanie J B, Tainta Mikel, Freund-Levi Yvonne, Frölich Lutz, Popp Julius, Peyratout Gwendoline, Tsolaki Magda, Verhey Frans, Vandenberghe Rik, Schaeverbeke Jolien, Blennow Kaj, van der Lee Sven J, Scheltens Philip, Pijnenburg Yolande A L, van der Flier Wiesje M, Teunissen Charlotte E, Zetterberg Henrik, Visser Pieter Jelle, Tijms Betty

Abstract excerpt

BACKGROUND: The apolipoprotein E (APOE) gene includes the strongest protective (ε2) and risk (ε4) variants for sporadic Alzheimer's disease (AD), but underlying mechanisms remain unclear. We studied APOE genotype effects on the cerebrospinal fluid (CSF) proteome. METHODS: Using untargeted tandem mass tag mass spectrometry, we analyzed CSF from 227 cognitively normal (CN) controls (A-T-), 165 CN A+, and 177...

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PMID: 41085205
DOI: 10.1002/alz.70738
PMCID: PMC12519502

Genes

APOE

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