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Article

Association of APOE genotype with blood-brain barrier permeability in neurodegenerative disorders.

Neurobiology of aging - 1 Aug 2024

Libri Ilenia, Silvestri Chiara, Caratozzolo Salvatore, Alberici Antonella, Pilotto Andrea, Archetti Silvana, Trainini Laura, Borroni Barbara, Padovani Alessandro, Benussi Alberto

Abstract excerpt

Apolipoprotein E (APOE) is recognized for its role in modulating blood-brain barrier (BBB) permeability in vitro, which may have significant implications for the pathogenesis and progression of neurodegenerative disorders. However, evidence in vivo is contrasting. This study explores the impact of APOE genotypes on BBB integrity among 230 participants experiencing cognitive impairment, encompassing cases of...

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Source

Identifiers

PMID: 38718740
DOI: 10.1016/j.neurobiolaging.2024.04.003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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