Armadillo nuclear import is regulated by cytoplasmic anchor Axin and nuclear anchor dTCF/Pan.

doi:10.1242/dev.128.11.2107

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Article

Armadillo nuclear import is regulated by cytoplasmic anchor Axin and nuclear anchor dTCF/Pan.

Development (Cambridge, England) - 1 Jun 2001

Tolwinski N S, Wieschaus E

Abstract excerpt

Drosophila melanogaster Armadillo plays two distinct roles during development. It is a component of adherens junctions, and functions as a transcriptional activator in response to Wingless signaling. In the current model, Wingless signal causes stabilization of cytoplasmic Armadillo allowing it to enter the nucleus where it can activate transcription. However, the mechanism of nuclear import and export remains to...

Topics

Active Transport, Cell Nucleus
Adaptor Proteins, Signal Transducing
Alleles
Animals
Armadillo Domain Proteins
Axin Protein
Carrier Proteins
Cell Nucleus
Cytoplasm
Drosophila Proteins
Drosophila melanogaster
Female
High Mobility Group Proteins
Insect Proteins
Male
Proto-Oncogene Proteins
Repressor Proteins
Signal Transduction

Source

Open in PubMed

Identifiers

PMID: 11493532
DOI: 10.1242/dev.128.11.2107

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