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Article

A new nuclear component of the Wnt signalling pathway.

Nature cell biology - 1 May 2002

Thompson Barry, Townsley Fiona, Rosin-Arbesfeld Rina, Musisi Hannah, Bienz Mariann

Abstract excerpt

The Wnt signalling pathway is pivotal in normal and malignant development. A key effector is Armadillo (Arm)/beta-catenin, which functions with TCF to transcribe Wnt target-genes. Here, we report the discovery of pygopus (pygo), whose mutant phenotypes specifically mimic loss-of-Wingless (Wg) signalling. pygo is required for dTCF-mediated transcription, but not for Wg-induced stabilization of Arm. Pygo is a...

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Identifiers

PMID: 11988739
DOI: 10.1038/ncb786

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A new nuclear component of the Wnt signalling pathway.PMID 11988739Read ↗

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Dissecting nuclear Wingless signalling: recruitment of the transcriptional co-activator Pygopus by a chain of adaptor proteins.Semantic proximity Read ↗

A novel conserved protein associates with the IFT-A complex to mediate nuclear translocation of β-catenin in Wg/Wnt-signalingSemantic proximity Read ↗

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