Article

Wnt target genes and where to find them

2017-05-24

Abstract excerpt

Wnt/β-catenin signaling is highly conserved throughout metazoans, is required for numerous essential events in development, and serves as a stem cell niche signal in many contexts. Misregulation of the pathway is linked to several human pathologies, most notably cancer. Wnt stimulation results in stabilization and nuclear import of β-catenin, which then acts as a transcriptional co-activator. Transcription factors...

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Literature Corpus work: b3b06f74-ac50-5eba-9ad6-9d4043159f1c
DOI: 10.12688/f1000research.11034.1

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