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A novel conserved protein associates with the IFT-A complex to mediate nuclear translocation of β-catenin in Wg/Wnt-signaling

2025-06-23

Abstract excerpt

<h4>Summary</h4> Wingless (Wg)/Wnt signaling is critical throughout development and tissue homeostasis and associated with many disease states. Canonical Wg/Wnt-signaling is mediated by β-catenin (Arm in Drosophila ) with IFT-A/Kinesin-2 complex promoting nuclear translocation of β-catenin/Arm upon pathway activation. Although IFT-A is essential for nuclear translocation of β-catenin/Arm, existing data suggests...

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Identifiers and source

Literature Corpus work
77480f6a-b62a-518d-9b64-0dd662b68a5f
DOI
10.1101/2025.06.21.660855
Open publication

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A novel conserved protein associates with the IFT-A complex to mediate nuclear translocation of β-catenin in Wg/Wnt-signalingDOI 10.1101/2025.06.21.660855
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