Article

Mutational scanning reveals substrate-assisted autoregulation of the WNT destruction complex

2025-10-18

Abstract excerpt

The β-catenin destruction complex (BDC) is a central node in WNT/β-catenin signaling, governing embryonic development and adult tissue homeostasis. Although recognized as a prime therapeutic target in colorectal cancer (CRC) for three decades, its dynamic architecture and biochemical complexity have hindered mechanistic understanding. Here, we systematically mapped the sequence-function landscape of the BDC using...

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Literature Corpus work: 3f901c38-c0a7-526d-b949-5f630f730943
DOI: 10.1101/2025.10.17.683169

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