Article

Wg/Wnt-signaling induced nuclear translocation of β-catenin is attenuated by a β-catenin peptide through its interaction with IFT-A in development and cancer cells

2023-06-14

Abstract excerpt

<h4>ABSTRACT</h4> Wnt/Wingless (Wg) signaling is critical for many developmental patterning processes and linked to diseases, including cancer. Canonical Wnt-signaling is mediated by β-catenin, Armadillo/Arm in Drosophila transducing signal activation to a nuclear response. The IFT-A/Kinesin-2 complex is required to promote the nuclear translocation of β-catenin/Arm. Here, we define a small conserved N-terminal...

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Literature Corpus work: 9665e55b-1115-5497-a698-e3a86b6f41a0
DOI: 10.1101/2023.06.14.544986

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