Article
Influence of CYP2D6 phenotype on the pharmacokinetics and pharmacodynamics of tramadol in patients treated for post-operative pain management.
Anaesthesia, critical care & pain medicine - 1 May 2026
Percevault Soizic, De La Gastine Blandine, Varin Laurent, Richard Nicolas, Fobe Fabienne, Plaud Benoît, Daccache Georges, Compere Vincent, Parienti Jean-Jacques, Coquerel Antoine, Loilier Magalie, Bleyzac Nathalie, Bourguignon Laurent, Lelong-Boulouard Véronique, Goutelle Sylvain
Abstract excerpt
INTRODUCTION: Tramadol is widely used in post-operative pain management. Concentrations of tramadol and its active metabolite O-demethyl tramadol (O-dT) are influenced by cytochrome P450 2D6 (CYP2D6) genotype. OBJECTIVES: The objectives of this study were to investigate the relationships between CYP2D6 phenotype and tramadol pharmacokinetics/ pharmacodynamics (PK/PD) in real life setting. METHODS: CYTRAM was a...
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