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Decreased Analgesic Effect of Tramadol in Japanese Patients with CYP2D6 Intermediate Metabolizers after Orthopedic Surgery.

Biological & pharmaceutical bulletin - 1 Jan 2023

Kamiya Takaki, Hira Daiki, Nakajima Ryo, Shinoda Kazuha, Motomochi Atsuko, Morikochi Aya, Ikeda Yoshito, Isono Tetsuichiro, Akabane Michiya, Ueshima Satoshi, Kakumoto Mikio, Imai Shinji, Morita Shin-Ya, Terada Tomohiro

Abstract excerpt

Tramadol is metabolized by CYP2D6 to an active metabolite, which in turn acts as an analgesic. This study aimed to investigate the impact of CYP2D6 genotype on the analgesic effect of tramadol in clinical practice. A retrospective cohort study was performed in patients treated with tramadol for postoperative pain after arthroscopic surgery for rotator cuff injury during April 2017-March 2019. The impact of CYP2D6...

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Identifiers

PMID: 37394642
DOI: 10.1248/bpb.b23-00030

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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