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Article

Role of Pharmacogenetics on Tramadol Pharmacokinetics: A Population Pharmacokinetic Model.

European journal of drug metabolism and pharmacokinetics - 1 Mar 2026

Soria-Chacartegui Paula, Würthwein Gudrun, Zubiaur Pablo, Almenara Susana, Ochoa Dolores, Abad-Santos Francisco, Hempel Georg

Abstract excerpt

BACKGROUND AND OBJECTIVE: Tramadol is a widely used opioid, and pharmacogenetics is partially responsible for the variability in its response. The objective was to develop a tramadol population pharmacokinetic (popPK) model including pharmacogenetic information. METHODS: A single oral dose of 37.5 mg tramadol + 400 mg ibuprofen arginine was administered to 24 European healthy volunteers, and 18 blood samples were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP2B6

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Source

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Identifiers

PMID: 41774388
DOI: 10.1007/s13318-026-00986-3
PMCID: PMC13031194

Genes

CYP2B6
CYP3A4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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