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Article

Concentrations of tramadol and O-desmethyltramadol enantiomers in different CYP2D6 genotypes.

Clinical pharmacology and therapeutics - 1 Jul 2007

Stamer U M, Musshoff F, Kobilay M, Madea B, Hoeft A, Stuber F

Abstract excerpt

The influence of CYP2D6 genotype and CYP2D6 inhibitors on enantiomeric plasma levels of tramadol and O-desmethyltramadol as well as response to tramadol was investigated. One hundred and seventy-four patients received one hundred intravenous tramadol 3 mg/kg for postoperative analgesia. Blood samples drawn 30, 90, and 180 min after administration were analyzed for plasma concentrations of the enantiomers (+)-,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17361124
DOI: 10.1038/sj.clpt.6100152

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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