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Article

Effect of the cytochrome P450 2D6*10 genotype on the pharmacokinetics of tramadol in post-operative patients.

Die Pharmazie - 1 Feb 2014

Xu Jing, Zhang Xiang-Cai, Lv Xiao-Qin, Xu Ying-Ying, Wang Guo-Xiang, Jiang Bo, Cai Long, Cai Xiu-Jun

Abstract excerpt

The cytochrome P450 2D6 (CYP2D6) is the most highly polymorphic isoenzyme of the cytochrome P-450-system, which affects the metabolism of one-fourth of all prescription drugs. Tramadol, a narcotic-like pain reliever used to treat moderate to severe pain, is primarily metabolized by CYP2D6. The CYP2D6*10 allele is the most common allele in the Chinese population. Therefore, we investigated the effects of CYP2D6*10...

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PMID: 24640604

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