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Article

Impact of CYP2D6 genetic polymorphism on tramadol pharmacokinetics and pharmacodynamics.

Molecular diagnosis & therapy - 1 Jan 2007

Gan Siew Hua, Ismail Rusli, Wan Adnan Wan Aasim, Zulmi Wan

Abstract excerpt

BACKGROUND AND OBJECTIVE: Tramadol is metabolized by the highly polymorphic enzyme cytochrome P450 (CYP)2D6. Patients with different CYP2D6 genotypes may respond differently to tramadol in terms of pain relief and adverse events. In this study, we compare the pharmacokinetics and effects of tramadol in Malaysian patients with different genotypes to establish the pharmacokinetic-pharmacodynamic relationship of...

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PMID: 17570739
DOI: 10.1007/BF03256239

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