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Article

Impact of CYP2D6 and CYP2B6 phenotypes on the response to tramadol in patients with acute post-surgical pain.

Clinical and translational science - 1 Jan 2024

Casajús Ana, Zubiaur Pablo, Alday Enrique, Soria-Chacartegui Paula, Saiz-Rodríguez Miriam, Gutierrez Lara, Aragonés Catalina, Campodónico Diana, Gómez-Fernández Antía, Navares-Gómez Marcos, Villapalos-García Gonzalo, Mejía-Abril Gina, Ochoa Dolores, Abad-Santos Francisco

Abstract excerpt

Tramadol is an important minor opioid prescribed for pain management. In this study, we analyzed the well-known impact of CYP2D6 genetic variation and 60 additional variants in eight candidate genes (i.e., ABCG2, SLCO1B1, CYP2D6, CYP2B6, CYP2C19, CYP2C9, CYP3A5, and CYP3A4) on tramadol efficacy and safety. Some 108 patients with pain after surgery admitted to a post-anesthesia care unit (PACU) and prescribed...

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Share to Analgesics, Opioid
Share to Cytochrome P-450 CYP2B6

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38140786
DOI: 10.1111/cts.13698
PMCID: PMC10787143

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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