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Article

The Effect of CYP2D6 Gene Polymorphism on Tramadol Efficacy in Total Knee Arthroplasty.

In vivo (Athens, Greece) - 1 Jan 2026

Gürbüz Erdi, Elfiky Abdo A, Ök Nusret, Köseler Aylin

Abstract excerpt

BACKGROUND/AIM: Tramadol, a centrally acting analgesic, is widely used in postoperative pain management. This study investigates the relationship between CYP2D6 gene polymorphisms and the efficacy of tramadol in patients undergoing total knee arthroplasty. PATIENTS AND METHODS: A total of 210 participants, including 110 TKA patients and 100 healthy controls, were enrolled. CYP2D6 genotyping was performed using...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Arthroplasty, Replacement, Knee

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Share to Polymorphism, Genetic

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Identifiers

PMID: 41760312
DOI: 10.21873/invivo.14273
PMCID: PMC12949914

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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