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Article

The Associations Between CYP2D6*10 C188T Polymorphism and Pharmacokinetics and Clinical Outcomes of Tramadol: A Systematic Review and Meta-analysis.

Pain medicine (Malden, Mass.) - 25 Dec 2020

Wen Qing-Hua, Zhang Zheng, Cai Wen-Ke, Lin Xiao-Qian, He Gong-Hao

Abstract excerpt

BACKGROUND: Tramadol is one of the most extensively used centrally acting synthetic opioid analgesics. Recently, a number of studies have explored the associations of the CYP2D6*10 C188T polymorphism with pharmacokinetic and clinical outcomes of tramadol. However, the results of these previous reports remain controversial. Therefore, a meta-analysis was needed to reach a consensus. METHODS: PubMed, EMBASE, and...

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PMID: 32488232
DOI: 10.1093/pm/pnaa140

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