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Mutational signatures: experimental design and analytical framework

14 Feb 2020

Abstract excerpt

Mutational signatures provide a powerful alternative for understanding the pathophysiology of cancer. Currently, experimental efforts aimed at validating and understanding the etiologies of cancer-derived mutational signatures are underway. In this review, we highlight key aspects of mutational signature experimental design and describe the analytical framework. We suggest guidelines and quality control measures...

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PMID: 32059681
DOI: 10.1186/s13059-020-1951-5

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