Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

HLA class I signal peptide variation predicts strength of NKG2A+ NK cell response to missing-self and risk of human disease.

Nature immunology - 1 Apr 2026

Lin Zhansong, Bashirova Arman A, Callahan Cian, Nelson George W, Robinson Emma, Viard Mathias, Tang Minzhong, Hildesheim Allan, Franke Andre, Rioux John D, Garcia-Beltran Wilfredo, Carrington Mary

Abstract excerpt

Natural killer (NK) cells expressing inhibitory receptors that recognize self human leukocyte antigen (HLA) class I molecules gain enhanced functionality-a process influenced by genetic polymorphism that dictates the strength of interactions between inhibitory receptors and their HLA ligands. Inhibitory CD94/NKG2A binds HLA-E loaded with epitopes derived from polymorphic HLA class I signal peptides (SPs). We...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Predisposition to Disease
Share to Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histocompatibility Antigens Class I

Share to HLA-E Antigens

Share to Killer Cells, Natural

Share to NK Cell Lectin-Like Receptor Subfamily C

Share to Polymorphism, Genetic

Share to Protein Sorting Signals

Source

Identifiers

PMID: 41781709
DOI: 10.1038/s41590-026-02436-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HLA class I signal peptide variation predicts strength of NKG2A+ NK cell response to missing-self and risk of human disease.PMID 41781709Read ↗

Innate receptors with high specificity for HLA class I–peptide complexesSemantic proximity Read ↗

MHC class I-specific inhibitory receptors and their ligands structure diverse human NK-cell repertoires toward a balance of missing self-response.Semantic proximity Read ↗

KIRCLE: An Analysis of Variations in KIR Genes in The Cancer Genome Atlas and UK BiobankSemantic proximity Read ↗

Tuning of human NK cells by endogenous HLA-C expression.Semantic proximity Read ↗

Polygenic polymorphism is associated with NKG2A repertoire and influences lymphocyte phenotype and function.Semantic proximity Read ↗

Allelic variation of KIR and HLA tunes the cytolytic payload and determines functional hierarchy of NK cell repertoires.Semantic proximity Read ↗

Class I HLA haplotypes form two schools that educate NK cells in different waysSemantic proximity Read ↗

Genetic control of human NK cell repertoire.Semantic proximity Read ↗

Trans-ethnic analysis of the human leukocyte antigen region for ulcerative colitis reveals shared but also ethnicity-specific disease associationsSemantic proximity Read ↗

HLA-E*01:01 + HLA-E*01:01 genotype confers less susceptibility to COVID-19, while HLA-E*01:03 + HLA-E*01:03 genotype is associated with more severe disease.Semantic proximity Read ↗

Canonical and cross-reactive binding of NK cell inhibitory receptors to HLA-C allotypes is dictated by peptides bound to HLA-CSemantic proximity Read ↗

Elevated HLA-A expression impairs HIV control through inhibition of NKG2A-expressing cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.