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Article

Polygenic polymorphism is associated with NKG2A repertoire and influences lymphocyte phenotype and function.

Blood advances - 22 Oct 2024

Le Luduec Jean-Benoît, Kontopoulos Theodota, Panjwani M Kazim, Sottile Rosa, Liu Hongtao, Schäfer Gesine, Massalski Carolin, Lange Vinzenz, Hsu Katharine C

Abstract excerpt

ABSTRACT: CD94/NKG2A is a heterodimeric receptor commonly found on natural killer (NK) and T cells, and its interaction with its ligand HLA-E on adjacent cells leads to inhibitory signaling and cell suppression. We have identified several killer cell lectin-like receptor (KLR)C1 (NKG2A) single nucleotide polymorphisms (SNPs) that are associated with NKG2A expression on NK cells, CD8+ T cells, and Vγ9/Vδ2+ T...

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Topics

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Share to C2 gene
Share to Histocompatibility Antigens Class I

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HLA-E Antigens

Share to Killer Cells, Natural

Share to NK Cell Lectin-Like Receptor Subfamily C

Share to Phenotype

Share to Polymorphism, Single Nucleotide

Source

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Identifiers

PMID: 39158076
DOI: 10.1182/bloodadvances.2024013508
PMCID: PMC11568789

Genes

C2
KLRC2
KLRK1

Provenance

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