Article
Genetic control of human NK cell repertoire.
Journal of immunology (Baltimore, Md. : 1950) - 1 Jul 2002
Shilling Heather G, Young Neil, Guethlein Lisbeth A, Cheng Nathalie W, Gardiner Clair M, Tyan Dolly, Parham Peter
Abstract excerpt
Through differential killer cell Ig-like receptor (KIR) and CD94:NKG2 gene expression, human NK cells generate diverse repertoires, each cell having an inhibitory receptor for autologous HLA class I. Using a new method for measuring repertoire difference that integrates multiple flow cytometry parameters, we found individual repertoire stability, but population variability. Correlating repertoire differences with...
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