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Article

Tuning of human NK cells by endogenous HLA-C expression.

Immunogenetics - 1 May 2020

Goodson-Gregg Frederick J, Krepel Stacey A, Anderson Stephen K

Abstract excerpt

NK cells are primarily responsible for detecting malignant or pathogen-infected cells, and their function is influenced both by stress-associated activating signals and opposing inhibitory signals from receptors that recognize self MHC. The receptors that produce this inhibitory signal shift from the NKG2A:HLA-E system to that of KIR:HLA as the NK cells mature. This maturation is associated with an increase in...

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Identifiers

PMID: 32219494
DOI: 10.1007/s00251-020-01161-x
PMCID: PMC7182622

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