Elevated HLA-A expression impairs HIV control through inhibition of NKG2A-expressing cells.

doi:10.1126/science.aam8825

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Article

Elevated HLA-A expression impairs HIV control through inhibition of NKG2A-expressing cells.

Science (New York, N.Y.) - 5 Jan 2018

Ramsuran Veron, Naranbhai Vivek, Horowitz Amir, Qi Ying, Martin Maureen P, Yuki Yuko, Gao Xiaojiang, Walker-Sperling Victoria, Del Prete Gregory Q, Schneider Douglas K, Lifson Jeffrey D, Fellay Jacques, Deeks Steven G, Martin Jeffrey N, Goedert James J, Wolinsky Steven M, Michael Nelson L, Kirk Gregory D, Buchbinder Susan, Haas David, Ndung'u Thumbi, Goulder Philip, Parham Peter, Walker Bruce D, Carlson Jonathan M, Carrington Mary

Abstract excerpt

The highly polymorphic human leukocyte antigen (HLA) locus encodes cell surface proteins that are critical for immunity. HLA-A expression levels vary in an allele-dependent manner, diversifying allele-specific effects beyond peptide-binding preference. Analysis of 9763 HIV-infected individuals from 21 cohorts shows that higher HLA-A levels confer poorer control of HIV. Elevated HLA-A expression provides enhanced...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29302013
DOI: 10.1126/science.aam8825
PMCID: PMC5933048

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