Article

KIRCLE: An Analysis of Variations in KIR Genes in The Cancer Genome Atlas and UK Biobank

2021-09-04

Abstract excerpt

<h4>Background</h4> Natural killer (NK) cells represent a critical component of the innate immune system’s response against cancer and viral infections, among other diseases. To distinguish healthy host cells from infected or tumor cells, killer immunoglobulin receptors (KIR) on NK cells bind and recognize Human Leukocyte Antigen (HLA) complexes on their target cells. Just like the HLAs they bind, these KIRs exhi...

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Literature Corpus work: 77cdf90c-b229-5702-95c6-1f29bd0a3f85
DOI: 10.1101/2021.09.02.458787

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