Article
Allelic variation of KIR and HLA tunes the cytolytic payload and determines functional hierarchy of NK cell repertoires.
Blood advances - 22 Aug 2023
Philippon Camille, Tao Sudan, Clement Dennis, Haroun-Izquierdo Alvaro, Kichula Katherine M, Netskar Herman, Brandt Ludwig, Oei Vincent Sheng, Kanaya Minoru, Lanuza Pilar Maria, Schaffer Marie, Goodridge Jodie P, Horowitz Amir, Zhu Faming, Hammer Quirin, Sohlberg Ebba, Majhi Rakesh Kumar, Kveberg Lise, Önfelt Björn, Norman Paul J, Malmberg Karl-Johan
Abstract excerpt
The functionality of natural killer (NK) cells is tuned during education and is associated with remodeling of the lysosomal compartment. We hypothesized that genetic variation in killer cell immunoglobulin-like receptor (KIR) and HLA, which is known to influence the functional strength of NK cells, fine-tunes the payload of effector molecules stored in secretory lysosomes. To address this possibility, we...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.