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Article

Structural basis for NKG2A/CD94 recognition of HLA-E

30 Apr 2008

Abstract excerpt

The NKG2x/CD94 (x = A, C, E) natural killer-cell receptors perform an important role in immunosurveillance by binding to HLA-E complexes that exclusively present peptides derived from MHC class I leader sequences, thereby monitoring MHC class I expression. We have determined the crystal structure of the NKG2A/CD94/HLA-E complex at 4.4-A resolution, revealing two critical aspects of this interaction. First, the...

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PMID: 18448674
DOI: 10.1073/pnas.0802736105

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