Article

Canonical and cross-reactive binding of NK cell inhibitory receptors to HLA-C allotypes is dictated by peptides bound to HLA-C

2016-12-27

Abstract excerpt

<h4>Background</h4> Human natural killer (NK) cell activity is regulated by a family of killer-cell Ig-like receptors (KIR) that bind human leucocyte antigen (HLA) class I. Combinations of KIR and HLA genotypes are associated with disease, including susceptibility to viral infection and disorders of pregnancy. KIR2DL1 binds HLA-C alleles of group C2 (Lys 80 ) and KIR2DL2 and KIR2DL3 bind HLA-C alleles of group C...

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Literature Corpus work: 50ecc02c-bbcb-57dd-a413-fedd9d82fe72
DOI: 10.1101/096958

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