Article

Mechanistic origins and evolutionary erosion of collateral sensitivity in a β-lactamase

2026-02-13

Abstract excerpt

<h4>ABSTRACT</h4> As antibiotic discovery stalls, exploiting collateral sensitivity, where resistance to one drug increases sensitivity to another, offers a promising route to extend the lifespan of existing drugs. However, the molecular origins and robustness of such trade-offs at the level of single resistance determinants remain poorly understood. Here, we examined a previously evolved trajectory of the β-lact...

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Literature Corpus work: f6b3cd50-87b4-5469-ae4e-c9270eb2e2f4
DOI: 10.64898/2026.02.12.705688

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