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Article

Association between CYP2A6 genetic variants and serum concentrations of highly persistent OH-PCBs and their parent PCBs in humans.

Journal of hazardous materials - 15 Feb 2026

Lyu Zhaoqing, Kobayashi Hatasu, Harada Sassa Mariko, Iwase Kodai, Haraguchi Koichi, Fujii Yukiko, Harada Kouji H

Abstract excerpt

Polychlorinated biphenyls (PCBs) are persistent environmental pollutants, whose hydroxylated metabolites (OH-PCBs) accumulate in humans and may exhibit more potent effects than their parent compounds. This study investigated serum concentrations of several persistent OH-PCBs and their parent PCBs in 129 Japanese participants, with a focus on the influence of the CYP2A6*4 gene deletion variant on OH-PCB formation...

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Share to Cytochrome P-450 CYP2A6
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41621302
DOI: 10.1016/j.jhazmat.2026.141224

Genes

CYP2A6
CYP2B6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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