Article
The impact of CYP2E1 genetic variability on risk assessment of VOC mixtures.
Regulatory toxicology and pharmacology : RTP - 1 Apr 2011
Pohl Hana R, Scinicariello Franco
Abstract excerpt
Humans are simultaneously exposed to multiple chemicals in the environment. Many of the chemicals use the same enzymes in their metabolic pathways. Competitive inhibition may occur as one of the possible interactions between the xenobiotics in human body. For example, many volatile organic compounds (VOCs) are metabolized using P450 enzymes, specifically CYP2E1. Inheritable gene alterations may result in changes...
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