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Article

In utero and lactational exposure to a complex mixture of polychlorinated biphenyls: toxicity in pups dependent on the Cyp1a2 and Ahr genotypes.

Toxicological sciences : an official journal of the Society of Toxicology - 1 Jan 2011

Curran Christine P, Vorhees Charles V, Williams Michael T, Genter Mary Beth, Miller Marian L, Nebert Daniel W

Abstract excerpt

Polychlorinated biphenyls (PCBs) are persistent toxic pollutants occurring as complex mixtures in the environment. Humans are known genetically to have > 60-fold differences in hepatic cytochrome P450 1A2 (CYP1A2) levels and > 12-fold differences in aryl hydrocarbon receptor (AHR) affinity, both of which could affect PCB pharmacokinetics. Thus, we compared Ahr(b1)_Cyp1a2(+/+) high-affinity AHR wild-type,...

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Source

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Identifiers

PMID: 20961953
DOI: 10.1093/toxsci/kfq314
PMCID: PMC3003831

Genes

AHR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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