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In utero and lactational exposure to PCBs in mice: adult offspring show altered learning and memory depending on Cyp1a2 and Ahr genotypes.

Environmental health perspectives - 1 Sept 2011

Curran Christine P, Nebert Daniel W, Genter Mary Beth, Patel Krishna V, Schaefer Tori L, Skelton Matthew R, Williams Michael T, Vorhees Charles V

Abstract excerpt

BACKGROUND: Both coplanar and noncoplanar polychlorinated biphenyls (PCBs) exhibit neurotoxic effects in animal studies, but individual congeners do not always produce the same effects as PCB mixtures. Humans genetically have > 60-fold differences in hepatic cytochrome P450 1A2 (CYP1A2)-uninduced basal levels and > 12-fold variability in aryl hydrocarbon receptor (AHR)affinity; because CYP1A2 is known to...

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Identifiers

PMID: 21571617
DOI: 10.1289/ehp.1002965
PMCID: PMC3230394

Genes

AHR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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In utero and lactational exposure to PCBs in mice: adult offspring show altered learning and memory depending on Cyp1a2 and Ahr genotypes.PMID 21571617Read ↗

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