Article
Genetic association of aromatic hydrocarbon receptor (AHR) and cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1) polymorphisms with dioxin blood concentrations among pregnant Japanese women.
Toxicology letters - 7 Jun 2013
Kobayashi Sumitaka, Sata Fumihiro, Sasaki Seiko, Ban Susumu, Miyashita Chihiro, Okada Emiko, Limpar Mariko, Yoshioka Eiji, Kajiwara Jumboku, Todaka Takashi, Saijo Yasuaki, Kishi Reiko
Abstract excerpt
Dioxins are metabolized by cytochrome P450, family 1 (CYP1) via the aromatic hydrocarbon receptor (AHR). We determined whether different blood dioxin concentrations are associated with polymorphisms in AHR (dbSNP ID: rs2066853), AHR repressor (AHRR; rs2292596), CYP1 subfamily A polypeptide 1 (CYP1A1; rs4646903 and rs1048963), CYP1 subfamily A polypeptide 2 (CYP1A2; rs762551), and CYP1 subfamily B polypeptide 1...