Article
Polychlorinated biphenyls, cytochrome P4501A1 polymorphism, and postmenopausal breast cancer risk.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jan 1999
Moysich K B, Shields P G, Freudenheim J L, Schisterman E F, Vena J E, Kostyniak P, Greizerstein H, Marshall J R, Graham S, Ambrosone C B
Abstract excerpt
In experimental systems, polychlorinated biphenyls (PCBs) induce cytochrome P4501A1 (CYP1A1), which is involved in metabolism of steroid hormones and polycyclic aromatic hydrocarbons in humans. A genetic polymorphism coding for a valine to isoleucine substitution in exon 7 has been associated wit...
Topics
- Aged
- Alleles
- Body Burden
- Body Mass Index
- Breast Neoplasms
- Case-Control Studies
- Chromatography, Gas
- Confidence Intervals
- Cytochrome P-450 CYP1A1
- Environmental Pollutants
- Exons
- Female
- Genotype