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Article

Protective PLCG2 variants associate with a delayed onset of Alzheimer's disease among heterozygous APOE ε4 carriers.

Alzheimer's research & therapy - 31 Jan 2026

Jeskanen Heli, Heikkinen Sami, Kervinen Inka, Lehtisalo Jenni, Ngandu Tiia, Willman Roosa-Maria, Rosa Jessica, Hoffmann Dorit, Leinonen Ville, Haapasalo Annakaisa, Takalo Mari, Martiskainen Henna, Hiltunen Mikko

Abstract excerpt

BACKGROUND: The PLCG2-P522R variant, which encodes a mildly hyperactive form of the PLCγ2 enzyme, has been identified as a protective genetic factor against Alzheimer’s disease (AD). Many recently discovered AD-associated microglial risk genes converge on the TREM2-PLCγ2 signaling pathway, emphasizing the importance of characterizing this signaling pathway to uncover potential therapeutic targets and biomarkers....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41620758
DOI: 10.1186/s13195-026-01957-1
PMCID: PMC12964913

Genes

PLCG2
APOE
TREM2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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