Article

The protective <i>PLCG2</i> variants delay Alzheimer’s disease onset age in <i>APOE ε</i>4 carriers

2025-09-25

Abstract excerpt

<h4>ABSTRACT</h4> <h4>INTRODUCTION</h4> We investigated the impact of protective PLCG2 -P522R and PLCG2 -3’UTR variants, and the TREM2 -R62H risk variant on Alzheimer’s disease (AD) onset age in relation to APOE ε4 status. Plasma-based biomarkers of the different variants were also explored. <h4>METHODS</h4> Kaplan-Meier and survival analyses were performed using FinnGen genotype and clinical endpoint data to a...

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Literature Corpus work: c8888c1e-77a7-5b1e-9625-a29efdf6f284
DOI: 10.1101/2025.09.22.25336304

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