Article
Multistep receptor binding of the hepatitis B virus preS1 domain.
Nature communications - 30 Jan 2026
Kobayashi Chisa, Ekimoto Toru, Ooka Koji, Mifune Junki, Matsuzawa Kayo, Que Lusheng, Li Yingfang, Kusunoki Atsuto, Morita Takeshi, Shionoya Kaho, Nagano Makoto, Wakae Kousho, Isogawa Masanori, Muramatsu Masamichi, Ohto Umeharu, Nomura Norimichi, Park Sam-Yong, Sureau Camille, Arai Munehito, Ikeguchi Mitsunori, Watashi Koichi
Abstract excerpt
The preS1 domain present on hepatitis B and D virus particles is an intrinsically disordered peptide (IDP) essential for recognizing the host receptor, sodium taurocholate co-transporting polypeptide (NTCP). However, it remains poorly understood how the disordered preS1 peptide achieves high-affinity binding through its conformational change. Here, we reveal a stepwise binding process through which multiple...
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