Article

Structure of hepatitis B/D antiviral drug Bulevirtide bound to its receptor protein NTCP

2024-01-22

Abstract excerpt

Cellular entry of the hepatitis B and D viruses (HBV/HDV) require binding of the viral surface polypeptide preS1 to the hepatobiliary transporter NTCP. This interaction can be blocked by bulevirtide (BLV, formerly Myrcludex B), a preS1 derivative and approved drug for treating HDV infection. To elucidate the basis of this inhibitory function, we determined a cryo-EM structure of BLV-bound human NTCP. BLV forms two...

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Identifiers and source

Literature Corpus work: e354583d-906a-5369-a651-8f5a81104001
DOI: 10.1101/2024.01.22.576510

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