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Article

Implications of seven NTCP mutations for receptor stability and Hepatitis B Virus infectivity: A computational analysis.

Mutation research - 1 Jan 2025

Kardoudi Amina, Redouane Salaheddine, Madihi Salma, Jackson Thomas, Benani Abdelouaheb

Abstract excerpt

Hepatitis B is a widespread viral infection and a major global public health concern. The human sodium taurocholate co-transporter polypeptide (NTCP) serves as a key receptor for the hepatitis B virus (HBV), enabling its entry into hepatocytes. Understanding how specific NTCP mutations influence its stability and interaction with HBV is critical for elucidating mechanisms of viral infectivity and resistance. This...

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PMID: 41290509
DOI: 10.1016/j.mrfmmm.2025.111921

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