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Article

N-terminal myristoylation-dependent masking of neutralizing epitopes in the preS1 attachment site of hepatitis B virus.

Journal of hepatology - 1 Jul 2011

Bremer Corinna M, Sominskaya Irina, Skrastina Dace, Pumpens Paul, El Wahed Ahmed Abd, Beutling Ulrike, Frank Ronald, Fritz Hans-Joachim, Hunsmann Gerhard, Gerlich Wolfram H, Glebe Dieter

Abstract excerpt

BACKGROUNDS & AIMS: The N-terminally myristoylated preS1 domain of the large hepatitis B surface protein (LHBs) mediates specific attachment of hepatitis B virus (HBV) to hepatocytes. Its B-cell epitopes leading to neutralization of infectivity are not yet characterized. METHODS: We inserted C- and N-terminal preS1 peptides into the most immunogenic region of HBV core particles, therewith immunized Balb/c mice...

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Identifiers

PMID: 21145866
DOI: 10.1016/j.jhep.2010.10.019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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