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Article

Structural basis for hepatitis B virus restriction by a viral receptor homologue.

Nature communications - 25 Oct 2024

Shionoya Kaho, Park Jae-Hyun, Ekimoto Toru, Takeuchi Junko S, Mifune Junki, Morita Takeshi, Ishimoto Naito, Umezawa Haruka, Yamamoto Kenichiro, Kobayashi Chisa, Kusunoki Atsuto, Nomura Norimichi, Iwata So, Muramatsu Masamichi, Tame Jeremy R H, Ikeguchi Mitsunori, Park Sam-Yong, Watashi Koichi

Abstract excerpt

Macaque restricts hepatitis B virus (HBV) infection because its receptor homologue, NTCP (mNTCP), cannot bind preS1 on viral surface. To reveal how mNTCP loses the viral receptor function, we here solve the cryo-electron microscopy structure of mNTCP. Superposing on the human NTCP (hNTCP)-preS1 complex structure shows that Arg158 of mNTCP causes steric clash to prevent preS1 from embedding onto the bile acid...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39455604
DOI: 10.1038/s41467-024-53533-6
PMCID: PMC11511851

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