Article
Structure of the bile acid transporter and HBV receptor NTCP.
Nature - 1 Jun 2022
Asami Jinta, Kimura Kanako Terakado, Fujita-Fujiharu Yoko, Ishida Hanako, Zhang Zhikuan, Nomura Yayoi, Liu Kehong, Uemura Tomoko, Sato Yumi, Ono Masatsugu, Yamamoto Masaki, Noda Takeshi, Shigematsu Hideki, Drew David, Iwata So, Shimizu Toshiyuki, Nomura Norimichi, Ohto Umeharu
Abstract excerpt
Chronic infection with hepatitis B virus (HBV) affects more than 290 million people worldwide, is a major cause of cirrhosis and hepatocellular carcinoma, and results in an estimated 820,000 deaths annually1,2. For HBV infection to be established, a molecular interaction is required between the large glycoproteins of the virus envelope (known as LHBs) and the host entry receptor sodium taurocholate...
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