Joint host-pathogen genomic analysis identifies hepatitis B virus mutations associated with human NTCP and HLA class I variation.

doi:10.1016/j.ajhg.2024.04.013

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Article

Joint host-pathogen genomic analysis identifies hepatitis B virus mutations associated with human NTCP and HLA class I variation.

American journal of human genetics - 6 Jun 2024

Xu Zhi Ming, Gnouamozi Gnimah Eva, Rüeger Sina, Shea Patrick R, Buti Maria, Chan Henry Ly, Marcellin Patrick, Lawless Dylan, Naret Olivier, Zeller Matthias, Schneuing Arne, Scheck Andreas, Junier Thomas, Moradpour Darius, Podlaha Ondrej, Suri Vithika, Gaggar Anuj, Subramanian Mani, Correia Bruno, Gfeller David, Urban Stephan, Fellay Jacques

Abstract excerpt

Evolutionary changes in the hepatitis B virus (HBV) genome could reflect its adaptation to host-induced selective pressure. Leveraging paired human exome and ultra-deep HBV genome-sequencing data from 567 affected individuals with chronic hepatitis B, we comprehensively searched for the signatures of this evolutionary process by conducting "genome-to-genome" association tests between all human genetic variants...

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Identifiers

PMID: 38749427
DOI: 10.1016/j.ajhg.2024.04.013
PMCID: PMC11179264

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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