Article

PreS1-decorated recombinant adenovirus encoding HBV antigens generates neutralizing humoral and cellular immunity

2026-01-30

Abstract excerpt

<h4>Background & Aims</h4> Achieving functional cure for chronic hepatitis B (CHB) will likely require a combinatorial approach targeting multiple aspects of the complex hepatitis B virus (HBV) life cycle and host adaptive immune responses. Here, we developed a therapeutic vaccination strategy targeting the PreS1 region of L-HBsAg, required for cellular entry of both hepatitis B and D viruses. An established pote...

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Literature Corpus work: f8c1b1c8-ec80-5a92-a8e6-3e289cc71982
DOI: 10.64898/2026.01.30.702816

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