Article
A new class of hepatitis B and D virus entry inhibitors, proanthocyanidin and its analogs, that directly act on the viral large surface proteins.
Hepatology (Baltimore, Md.) - 1 Apr 2017
Tsukuda Senko, Watashi Koichi, Hojima Taichi, Isogawa Masanori, Iwamoto Masashi, Omagari Katsumi, Suzuki Ryosuke, Aizaki Hideki, Kojima Soichi, Sugiyama Masaya, Saito Akiko, Tanaka Yasuhito, Mizokami Masashi, Sureau Camille, Wakita Takaji
Abstract excerpt
Introduction of direct-acting antivirals against hepatitis C virus (HCV) has provided a revolutionary improvement in the treatment outcome. In contrast to HCV, however, the strategy for developing new antiviral agents against hepatitis B virus (HBV), especially viral-targeting compounds, is limited because HBV requires only four viral genes for its efficient replication/infection. Here, we identify an oligomeric...
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