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Article

GenBlosum: On Determining Whether Cancer Mutations Are Functional or Random.

Genes - 2 Jan 2026

Leyva Alejandro, Khan Niazi Muhammad Khalid

Abstract excerpt

BACKGROUND: Genetic mutations have proven to be the epicenters of cancer and disease progression. Traditional WXS sequencing and BLOSUM scoring can be used to infer the evolutionary conservation of amino acid substitutions, though these approaches are not informed by probable base pair sequence changes. Within gene mutation analysis, most tools focus on amino acid conservation or codon switching independently,...

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Identifiers

PMID: 41595475
DOI: 10.3390/genes17010055
PMCID: PMC12840647

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PIK3CA
TP53

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 14 Sept 2026.

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