Attribution of Cancer Origins to Endogenous, Exogenous, and Preventable Mutational Processes.

Abstract excerpt

Mutational processes in tumors create distinctive patterns of mutations, composed of neutral "passenger" mutations and oncogenic drivers that have quantifiable effects on the proliferation and survival of cancer cell lineages. Increases in proliferation and survival are mediated by natural selection, which can be quantified by comparing the frequency at which we detect substitutions to the frequency at which we...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Carcinogenesis
• Share to Exome Sequencing
• Share to Mutation